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Most IAPs have a RING domain at their C-terminus that is required for ubiquitination of their substrates as well as auto-ubiquitination of some members including c-IAP1, c-IAP2 and X-linked inhibitor of apoptosis (XIAP) 61,62
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It is still a useful benchmark: compare it against the measurement error of reading 2.5 units on a U-100 syringe, where a single unit misread at 10 mg/mL is a 40% error on a 0.25 mg step
[16] Targeted disruption of the mitochondrial GPX4 isoform (mGPX4) caused infertility in male mice and disruption of the nuclear GPX4 isoform (nGPX4) reduced the structural stability of sperm chromatin, yet both knockout mouse models (for mGPX4 and nGPX4) were fully viable
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